POLR3E Gene Summary [Human]
Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in defense response to virus; innate immune response; and transcription, DNA-templated. Located in nucleoplasm. Part of RNA polymerase III complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | POLR3E |
| Official Name | RNA polymerase III subunit E [Source:HGNC Symbol;Acc:HGNC:30347] |
| Ensembl ID | ENSG00000058600 |
| Bio databases IDs | |
| Aliases | RNA polymerase III subunit E |
| Synonyms | C37, KIAA1452, polymerase (RNA) III (DNA directed) polypeptide E, RGD1308086, RNA polymerase III subunit E, RPC5, SIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR3E often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- YXXP domain
- DNA-directed RNA polymerase III subunit RPC5 C-terminal
- transcription regulator
- RPC5 protein
- Sh3 domain binding motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR3E gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- innate immune response
- defense response to virus
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm