Bccip Gene Summary [Mouse]
Predicted to enable kinase regulator activity and tubulin binding activity. Involved in DNA damage response; microtubule anchoring; and mitotic spindle organization. Located in centrosome and mitotic spindle pole. Is expressed in several structures, including axial musculature; brain ventricular layer; orbito-sphenoid; submandibular gland primordium; and thymus primordium. Orthologous to human BCCIP (BRCA2 and CDKN1A interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bccip |
| Official Name | BRCA2 and CDKN1A interacting protein [Source:MGI Symbol;Acc:MGI:1913415] |
| Ensembl ID | ENSMUSG00000030983 |
| Bio databases IDs | |
| Aliases | BRCA2 and CDKN1A interacting protein |
| Synonyms | 1110013J05RIK, BRCA2 and CDKN1A interacting protein, TOK-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bccip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tubulin binding
- kinase regulator
- protein binding
- BCCIP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- invasive ductal breast cancer
- cancer
- infiltrating ductal breast carcinoma
- cervical cancer
- brain cancer
- central nervous system cancer
- head and neck cancer
- head and neck neoplasia
regulates
role in cell
- differentiation
- formation
- growth
- homologous recombination repair
- formation in
- homologous recombination repair in
- processing in
- assembly
- organization
- confusion in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- centriole
- cytosol
- nuclear foci
- nucleoplasm
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bccip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroendocrine cell differentiation
- DNA repair
- microtubule anchoring
- mitotic spindle organization
- microtubule cytoskeleton organization
- regulation of cyclin-dependent protein kinase activity
- spindle assembly involved in mitosis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- centriole
- nuclear cyclin-dependent protein kinase holoenzyme complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- kinase regulator activity