Stk33 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in manchette assembly and protein autophosphorylation. Located in manchette. Is expressed in several structures, including central nervous system; heart; lung; sensory organ; and testis. Human ortholog(s) of this gene implicated in colorectal cancer; depressive disorder; and spermatogenic failure 93. Orthologous to human STK33 (serine/threonine kinase 33). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stk33 |
| Official Name | serine/threonine kinase 33 [Source:MGI Symbol;Acc:MGI:2152419] |
| Ensembl ID | ENSMUSG00000031027 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 33 |
| Synonyms | 4921505G21Rik, LOC105376537, LOC687171, serine/threonine kinase 33, SPGF93 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stk33 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metabolic syndrome X
- small cell lung carcinoma
- small cell lung cancer
- Moyamoya disease
- colon carcinoma
- colon epithelial cancer
- chronic lymphocytic leukemia
- asthenozoospermia
- restless legs syndrome
role in cell
- assembly
- abnormal morphology
- ploidy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- manchette
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stk33 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity