Mertk Gene Summary [Mouse]
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Acts upstream of or within several processes, including neutrophil clearance; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and substrate adhesion-dependent cell spreading. Predicted to be located in cytoplasm; extracellular space; and photoreceptor outer segment. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; immune system; and retina. Used to study autoimmune disease. Human ortholog(s) of this gene implicated in retinitis pigmentosa 38. Orthologous to human MERTK (MER proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mertk |
| Official Name | MER proto-oncogene tyrosine kinase [Source:MGI Symbol;Acc:MGI:96965] |
| Ensembl ID | ENSMUSG00000014361 |
| Bio databases IDs | |
| Aliases | MER proto-oncogene tyrosine kinase |
| Synonyms | c-Eyk, c-Mer, Eyk, MER, MER proto-oncogene tyrosine kinase, MER proto-oncogene, tyrosine kinase, nmf12, Nyk, RDY, RP38, Tyro12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mertk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- ATP-binding domain
- ectodomain
- immunoglobulin domain
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- protein binding
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- cytoplasmic domain
- FN3
- Immunoglobulin like
- transmembrane domain
- immunoglobulin-like protein domain
- intracellular domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mertk gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- hepatocellular carcinoma
- neoplasia
- glioblastoma
- cancer
- autoimmune disease
- acute myeloid leukemia
- gastrointestinal neuroendocrine tumor
- metastatic malignant gastrointestinal neuroendocrine tumor
- myocardial infarction
role in cell
- proliferation
- activation in
- quantity
- expression in
- phosphorylation in
- production in
- number
- survival
- cell death
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- photoreceptor outer segments
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mertk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vagina development
- multicellular organismal development
- retina development in camera-type eye
- spermatogenesis
- nervous system development
- cell-cell signaling
- transmembrane receptor protein tyrosine kinase signaling pathway
- negative regulation of lymphocyte activation
- cell surface receptor signaling pathway
- protein phosphorylation
- negative regulation of leukocyte apoptotic process
- natural killer cell differentiation
- substrate adhesion-dependent cell spreading
- phagocytosis
- positive regulation of kinase activity
- establishment of localization in cell
- positive regulation of phagocytosis
- negative regulation of cytokine production
- platelet activation
- cell migration
- positive regulation of protein kinase B signaling cascade
- secretion by cell
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- receptor complex
- plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transmembrane receptor protein tyrosine kinase activity