Rab33a Gene Summary [Mouse]
This gene encodes a member of the Ras-related small GTPases, which regulate membrane trafficking in organelles and transport vesicles. This protein has been reported to be expressed in lymphocytes and in regions of the mouse brain, specifically the cortex, hippocampus and also the olfactory bulb. The ortholog of this protein in rat has been characterized and may participate in anterograde trafficking of synaptophysin-positive vesicles to the plasma membrane. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | Rab33a |
| Official Name | RAB33A, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:109493] |
| Ensembl ID | ENSMUSG00000031104 |
| Bio databases IDs | |
| Aliases | RAB33A, member RAS oncogene family |
| Synonyms | RAB33A, member RAS oncogene family, RabS10, RGD1563280 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab33a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- 50S ribosome-binding GTPase
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- ADP-ribosylation factor family
- small GTP-binding protein domain
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- ECBD 3164
- ovalbumin
role in cell
- growth
- formation
- quantity
- outgrowth
- axonal transport
- activation
- accumulation
- cross-presentation by
- outgrowth in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Golgi membrane
- growth cone
- secretory vesicles
- perikaryon
- dendrites
- axonal shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab33a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- Rab protein signal transduction
- antigen processing and presentation
Cellular Component
Where in the cell the gene product is active
- endosome
- Golgi membrane
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity