Mapk13 Gene Summary [Mouse]
Predicted to enable ATP binding activity and MAP kinase activity. Predicted to be involved in several processes, including cellular response to anisomycin; cellular response to sodium arsenite; and cellular response to sorbitol. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; respiratory system; and sensory organ. Orthologous to human MAPK13 (mitogen-activated protein kinase 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mapk13 |
| Official Name | mitogen-activated protein kinase 13 [Source:MGI Symbol;Acc:MGI:1346864] |
| Ensembl ID | ENSMUSG00000004864 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 13 |
| Synonyms | mitogen-activated protein kinase 13, p38delta, p38delta MAPK, P38 MAP KINASE delta, P38 MAP KINASE δ, P38 δ, PRKM13, SAPK4, Serk4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mapk13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- Protein kinase domain
- phosphorylation site
- kinase
- Serine/Threonine protein kinases, catalytic domain
- short length of linker loop 12
- Protein Kinases, catalytic domain
- MAP kinase
- TGY dual phosphorylation site
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Mapk13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 4-1BB Signaling in T Lymphocytes
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- April Mediated Signaling
- ATM Signaling
- B Cell Activating Factor Signaling
- BMP signaling pathway
- CD40 Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- FGF Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- IL-22 Signaling
- Mouse Embryonic Stem Cell Pluripotency
- Parkinson's Signaling
- PEDF Signaling
- RANK Signaling in Osteoclasts
- Role of MAPK Signaling in the Pathogenesis of Influenza
- Toll-like Receptor Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- papillomatosis
- benign neoplasia
- neoplasia
- metastasis
- advanced cancer
- obesity
- hepatic steatosis
role in cell
- apoptosis
- transmembrane potential
- expression in
- cell death
- phosphorylation in
- function
- migration
- growth
- production in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mapk13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to sorbitol
- positive regulation of inflammatory response
- cellular response to UV
- response to osmotic stress
- cellular response to interleukin-1
- cellular response to hydrogen peroxide
- peptidyl-serine phosphorylation
- positive regulation of interleukin-6 production
- intracellular signal transduction
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- MAP kinase activity
- protein serine/threonine kinase activity