Fgf16 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Predicted to be involved in several processes, including fibroblast growth factor receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of endothelial cell chemotaxis to fibroblast growth factor. Predicted to act upstream of or within positive regulation of brown fat cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including branchial arch; heart; inner ear; nose; and tongue. Human ortholog(s) of this gene implicated in syndactyly type 8. Orthologous to human FGF16 (fibroblast growth factor 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf16 |
| Official Name | fibroblast growth factor 16 [Source:MGI Symbol;Acc:MGI:1931627] |
| Ensembl ID | ENSMUSG00000031230 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 16 |
| Synonyms | Fgf4c, fibroblast growth factor 16, MF4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- protein binding
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf16 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- fusion of metacarpals IV and V
- osteoporosis
- hypoplasia
role in cell
- expression in
- proliferation
- invasion by
- invasiveness
- epithelial-mesenchymal transition
- glycolysis in
- mitogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAP kinase activity
- response to temperature stimulus
- signal transduction
- positive regulation of cell proliferation
- cell-cell signaling
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- organ morphogenesis
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- cell differentiation
- regulation of endothelial cell proliferation
- positive regulation of endothelial cell chemotaxis to fibroblast growth factor
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- fibroblast growth factor receptor binding