Cish Gene Summary [Mouse]
Predicted to enable cytokine receptor binding activity. Acts upstream of or within negative regulation of cytokine-mediated signaling pathway. Located in plasma membrane. Is expressed in heart; liver; retina; and thymus primordium. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human CISH (cytokine inducible SH2 containing protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cish |
| Official Name | cytokine inducible SH2-containing protein [Source:MGI Symbol;Acc:MGI:103159] |
| Ensembl ID | ENSMUSG00000032578 |
| Bio databases IDs | |
| Aliases | cytokine inducible SH2-containing protein |
| Synonyms | BACTS2, CIS, CIS-1, cytokine inducible SH2-containing protein, F17, F23, G18, SOCS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cish often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- elongin B/C binding domain
- SOCS
- Src homology 2 (SH2) domain
- protein binding
- Cullin-box
Pathways
Biological processes and signaling networks where the Cish gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic sclerosis
- susceptibility to malaria
- lung cancer
- pulmonary fibrosis
- serum transfer induced arthritis
- hyperplasia
- insulin-dependent diabetes mellitus
- hypersensitivity reaction type I
- susceptibility to bacteremia type 2
- high-fat diet-induced obesity
role in cell
- production in
- proliferation
- expression in
- activation in
- phosphorylation in
- degradation in
- quantity
- activation
- number
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cish gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of signal transduction
- regulation of cell growth
- phosphatidylinositol phosphorylation
- protein kinase C-activating G-protein coupled receptor signaling pathway
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- 1-phosphatidylinositol-3-kinase regulator activity