Slc25a15 Gene Summary [Mouse]
Predicted to enable L-amino acid transmembrane transporter activity and antiporter activity. Predicted to be involved in L-arginine transmembrane transport; L-lysine transmembrane transport; and mitochondrial L-ornithine transmembrane transport. Located in mitochondrial inner membrane. Is expressed in liver; metanephros; midgut; and retina. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; citrullinemia; and ornithine translocase deficiency. Orthologous to human SLC25A15 (solute carrier family 25 member 15). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc25a15 |
| Official Name | solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 [Source:MGI Symbol;Acc:MGI:1342274] |
| Ensembl ID | ENSMUSG00000031482 |
| Bio databases IDs | |
| Aliases | solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 |
| Synonyms | Ab1-114, D13S327, D630044L02Rik, HHH, LNC-HC, ORC1, ORNT1, solute carrier family 25 member 15, solute carrier family 25 (mitochondrial carrier ornithine transporter), member 15 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc25a15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- organic cation transporter
- lysine transporter
- ornithine transporter
- Mitochondrial carrier protein
- transmembrane domain
- antiporter
- L-amino acid transporter
- basic amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- hyperornithinemia-hyperammonemia-homocitrullinuria syndrome
- arrhythmia
- hereditary breast and/or ovarian cancer
regulates
- L-lysine
- L-serine
- citrulline
- L-ornithine
- arginine
- L-arginine
role in cell
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc25a15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- urea cycle
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- membrane
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- L-ornithine transmembrane transporter activity
- L-lysine transmembrane transporter activity
- antiporter activity