Fgf20 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity; growth factor activity; and receptor-receptor interaction. Involved in regulation of neuron differentiation. Acts upstream of or within inner ear auditory receptor cell differentiation and regulation of cardiac muscle cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including cranium; jaw; limb; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human FGF20 (fibroblast growth factor 20). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf20 |
| Official Name | fibroblast growth factor 20 [Source:MGI Symbol;Acc:MGI:1891346] |
| Ensembl ID | ENSMUSG00000031603 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 20 |
| Synonyms | Fgf4a, fibroblast growth factor 20, RHDA2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- binding protein
- protein binding
- receptor binding
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal hypodysplasia/aplasia type 2
- hearing loss
role in cell
- proliferation
- apoptosis
- number
- differentiation
- survival
- development
- abnormal morphology
- condensation
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dopamine secretion
- signal transduction
- positive regulation of cell proliferation
- regulation of cardiac muscle cell proliferation
- cell-cell signaling
- fibroblast growth factor receptor signaling pathway
- positive regulation of MAPK cascade
- negative regulation of neuron apoptotic process
- organ morphogenesis
- auditory receptor cell differentiation
- positive regulation of gene expression
- positive regulation of protein phosphorylation
- positive regulation of ERK1 and ERK2 cascade
- cell differentiation
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- heparan sulfate proteoglycan binding
- receptor binding
- fibroblast growth factor receptor binding