Map3k4 Gene Summary [Mouse]
Enables protein kinase activity. Involved in intracellular signal transduction and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and placenta development. Located in cytoplasm. Is expressed in several structures, including central nervous system; future brain; and genitourinary system. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Map3k4 |
| Official Name | mitogen-activated protein kinase kinase kinase 4 [Source:MGI Symbol;Acc:MGI:1346875] |
| Ensembl ID | ENSMUSG00000014426 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 4 |
| Synonyms | D17Rp17, D17Rp17e, MAPK3K4, MAPKKK4, Mek4b, MEKK 4, mitogen-activated protein kinase kinase kinase 4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, TAS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Map3k4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- GADD45 binding domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- MEKK4 N-terminal
- coiled-coil domain
- protein binding
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Map3k4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- G-Protein Coupled Receptor Signaling
- GADD45 Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- Hepatic Cholestasis
- HGF Signaling
- Leukocyte Extravasation Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insomnia
- hepatocellular carcinoma
- coronary artery disease
- myocardial infarction
- colon carcinoma
- epithelial cancer
- endometrium tumor
- liver cancer
- endometriosis
role in cell
- expression in
- growth
- apoptosis
- accumulation in
- quantity
- necrosis
- activation in
- differentiation
- invasion
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Endoplasmic Reticulum
- perinuclear vesicles
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Map3k4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- positive regulation of telomerase activity
- positive regulation of JUN kinase activity
- male germ-line sex determination
- chorionic trophoblast cell differentiation
- positive regulation of telomere maintenance via telomerase
- regulation of gene expression
- response to UV-C
- placenta development
- intracellular signal transduction
- positive regulation of p38MAPK cascade
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- MAP kinase kinase kinase activity