Pgls Gene Summary [Mouse]
Predicted to enable 6-phosphogluconolactonase activity and monosaccharide binding activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in cerebellum; hemolymphoid system; and thymus primordium. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pgls |
| Official Name | 6-phosphogluconolactonase [Source:MGI Symbol;Acc:MGI:1913421] |
| Ensembl ID | ENSMUSG00000031807 |
| Bio databases IDs | |
| Aliases | 6-phosphogluconolactonase |
| Synonyms | 1110030K05Rik, 6PGL, 6-phosphogluconolactonase, HEL-S-304, Plgs |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pgls often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SugarP_isomerase
- monosaccharide binding
- 6-phosphogluconolactonase
- Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pgls gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- pentose-phosphate shunt, oxidative branch
- pentose-phosphate shunt
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- 6-phosphogluconolactonase activity