LDHD
LDHD Gene Summary
The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LDHD |
| Official Name | lactate dehydrogenase D [Source:HGNC Symbol;Acc:HGNC:19708] |
| Ensembl ID | ENSG00000166816 |
| Bio databases IDs | |
| Aliases | lactate dehydrogenase D |
| Synonyms | 4733401P21Rik,Ac2-202,D8BWG1320E,DLACD,DLD,lactate dehydrogenase D |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding domain
- FAD linked oxidases, C-terminal domain
- glycolate oxidase, subunit GlcD
- D-lactate dehydrogenase (cytochrome)
- enzyme
- protein binding
- D-lactate dehydrogenase
Pathways
Biological processes and signaling networks where the LDHD gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ZGPAT
- ZC3HAV1
- ZKSCAN1
- CAND1
- CKAP2
- CGAS
- MAGT1
- RPL22L1
- REPIN1
- ZW10
disease
- organismal death
- lactic aciduria due to D-lactic acid
- D-lactic aciduria with gout
- renal clear cell adenocarcinoma
- renal clear cell cancer
- pervasive developmental disorder
- androgenic alopecia
regulated by
- metribolone
- FOXO3
- CDK4
- ERN1
- YAP1
- glutamine
- PEX5
- AKR1C1
- CLUH
- TYA-018
regulates
- lactic acid
- pyruvic acid
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the LDHD gene, providing context for its role in the cell.
CELLULAR COMPONENT
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- FAD binding
- D-lactate dehydrogenase (cytochrome) activity
- protein binding
- flavin adenine dinucleotide binding
- D-lactate dehydrogenase activity