Bco2 Gene Summary [Mouse]
Enables beta,beta-carotene-9',10'-cleaving oxygenase activity. Involved in isoprenoid catabolic process; regulation of mitochondrial membrane potential; and regulation of reactive oxygen species metabolic process. Acts upstream of or within retinal metabolic process and xanthophyll metabolic process. Located in mitochondrion. Is expressed in brain; embryo; liver; placenta; and yolk sac. Orthologous to human BCO2 (beta-carotene oxygenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bco2 |
| Official Name | beta-carotene oxygenase 2 [Source:MGI Symbol;Acc:MGI:2177469] |
| Ensembl ID | ENSMUSG00000032066 |
| Bio databases IDs | |
| Aliases | beta-carotene oxygenase 2 |
| Synonyms | Ab2-079, BCDO2, Bcmo2, B-Diox2, B-DIOX-II, beta-carotene oxygenase 2, CMO2, β-carotene oxygenase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bco2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PLN02258
- Retinal pigment epithelial membrane protein
- enzyme
- single donor 2 atom incorporation:oxygen oxidoreductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bco2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carotene metabolic process
- regulation of mitochondrial membrane potential
- regulation of reactive oxygen species metabolic process
- retinoic acid metabolic process
- carotene catabolic process
- retinal metabolic process
- xanthophyll catabolic process
- carotenoid metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
- beta-carotene 15,15'-monooxygenase activity
- metal ion binding
- 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity
- carotenoid dioxygenase activity