Spon2 Gene Summary [Mouse]
Enables antigen binding activity and lipopolysaccharide binding activity. Acts upstream of or within several processes, including defense response to other organism; opsonization; and positive regulation of cytokine production. Located in extracellular matrix and extracellular space. Orthologous to human SPON2 (spondin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Spon2 |
| Official Name | spondin 2, extracellular matrix protein [Source:MGI Symbol;Acc:MGI:1923724] |
| Ensembl ID | ENSMUSG00000037379 |
| Bio databases IDs | |
| Aliases | spondin 2, extracellular matrix protein |
| Synonyms | 2310045I24Rik, DIL-1, LOC100130872-SPON2, LOC100361829, LOC100910790, LOC171569, MINDIN, M-SPONDIN, spondin 2, spondin 2, extracellular matrix protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spon2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Thrombospondin type 1 repeats
- Thrombospondin type 1 domain
- antigen binding
- protein binding
- receptor binding
- Spondin-like TSP1 domain
- lipopolysaccharide binding
- Spondin_N
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- squamous cell lung cancer
- lung adenocarcinoma
- infection
- neoplasia
- lung adenocarcinoma formation
- glioblastoma
- glioblastoma cancer
- backache
role in cell
- expression in
- quantity
- clearance
- activation
- migration
- adhesion
- response
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spon2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macrophage cytokine production
- induction of bacterial agglutination
- cellular response to lipopolysaccharide
- mast cell mediated immunity
- innate immune response
- defense response to virus
- cell adhesion
- positive regulation of tumor necrosis factor production
- positive regulation of interleukin-6 production
- defense response to fungus
- opsonization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- antigen binding
- metal ion binding
- lipopolysaccharide binding