Robo4 Gene Summary [Mouse]
Enables signaling receptor activity. Acts upstream of or within negative regulation of blood vessel endothelial cell migration. Located in external side of plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; neural retina; submandibular gland; and vascular system. Human ortholog(s) of this gene implicated in aortic valve disease 3. Orthologous to human ROBO4 (roundabout guidance receptor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Robo4 |
| Official Name | roundabout guidance receptor 4 [Source:MGI Symbol;Acc:MGI:1921394] |
| Ensembl ID | ENSMUSG00000032125 |
| Bio databases IDs | |
| Aliases | roundabout guidance receptor 4 |
| Synonyms | 1200012D01Rik, AOVD3, ECSM4, MRB, Robo4l, roundabout guidance receptor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Robo4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- FN3
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Fibronectin type 3 domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- preeclampsia
- metastasis
- thoracic aortic aneurysm
- aortic valve disease type 3
- Klinefelter syndrome
- venous thromboembolism
- overall survival
- progression free survival
- endometrial cancer
role in cell
- expression in
- migration
- permeability
- invasion by
- accumulation
- mobilization
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Robo4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- dendrite self-avoidance
- axon guidance
- homophilic cell adhesion
- regulation of cell migration
- establishment of endothelial barrier
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity