Ccnb2 Gene Summary [Mouse]

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within several processes, including T cell homeostasis; meiosis I cell cycle process; and thymus development. Located in cytoplasm and membrane. Is expressed in several structures, including blastocyst; central nervous system; early embryo; gonad; and placenta. Orthologous to human CCNB2 (cyclin B2). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ccnb2
Official Name
cyclin B2 [Source:MGI Symbol;Acc:MGI:88311]
Ensembl ID
ENSMUSG00000032218
Bio databases IDs NCBI: 12442 Ensembl: ENSMUSG00000032218
Aliases cyclin B2
Synonyms Clb2, CycB2, cyclin B2, HsT17299
Species
Mouse, Mus musculus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccnb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • cyclin box
  • Cyclin box fold superfamily
  • Cyclin, N-terminal domain
  • protein binding
  • domain present in cyclins, TFIIB and Retinoblastoma

Pathways

Biological processes and signaling networks where the Ccnb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • non-small cell lung carcinoma
  • liver cancer
  • epithelial cancer
  • neoplasia
  • non-small cell lung cancer
  • lung adenocarcinoma
  • metastasis
  • lymphomagenesis
  • lung adenocarcinoma formation
  • ovarian cancer
regulated by
regulates
role in cell
  • number
  • proliferation
  • cell cycle progression
  • migration
  • quantity
  • dissociation
  • epithelial-mesenchymal transition in
  • sensitization
  • homeostasis
  • mitosis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • membrane fraction
  • microtubule cytoskeleton
  • cellular membrane
  • ribosome
  • centrosome
  • Golgi Apparatus
  • cytosol
  • mitotic spindle
  • plasma

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccnb2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell division
  • in utero embryonic development
  • spindle assembly involved in female meiosis I
  • regulation of growth
  • meiotic G2/MI transition
  • T cell homeostasis
  • thymus development
  • regulation of cyclin-dependent protein kinase activity

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • centrosome
  • microtubule cytoskeleton
  • cytoplasm
  • cyclin-dependent protein kinase holoenzyme complex
  • membrane
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • cyclin-dependent protein kinase regulator activity
  • cadherin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.