Crabp1 Gene Summary [Mouse]
Predicted to enable fatty acid binding activity and retinoic acid binding activity. Predicted to be involved in fatty acid transport. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human CRABP1 (cellular retinoic acid binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crabp1 |
| Official Name | cellular retinoic acid binding protein I [Source:MGI Symbol;Acc:MGI:88490] |
| Ensembl ID | ENSMUSG00000032291 |
| Bio databases IDs | |
| Aliases | cellular retinoic acid binding protein I |
| Synonyms | Cellular retinoic acid binding, cellular retinoic acid binding protein 1, cellular retinoic acid binding protein I, CRABP, CRABP-I, RBP5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crabp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- protein binding
- retinoid binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the Crabp1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- aortic valve calcification
- uterine serous papillary cancer
- diabetic nephropathy
- papillary thyroid carcinoma
- papillary thyroid cancer
- androgenic alopecia
- nodular goiter
- polydactyly
regulates
- tretinoin
- CRABP2
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crabp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid transport
- signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- fatty acid binding
- protein binding
- retinal binding
- retinol binding
- retinoid binding