Icmt Gene Summary [Mouse]
Enables cAMP response element binding protein binding activity and protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity. Involved in CAAX-box protein maturation. Acts upstream of or within several processes, including C-terminal protein methylation; TOR signaling; and determination of adult lifespan. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ICMT (isoprenylcysteine carboxyl methyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Icmt |
| Official Name | isoprenylcysteine carboxyl methyltransferase [Source:MGI Symbol;Acc:MGI:1888594] |
| Ensembl ID | ENSMUSG00000039662 |
| Bio databases IDs | |
| Aliases | isoprenylcysteine carboxyl methyltransferase |
| Synonyms | 1700008E11RIK, fcmt, Gm13095, HSTE14, isoprenylcysteine carboxyl methyltransferase, MST098, MSTP098, PCCMT, PCMT, PPMT, STE14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Icmt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-S-isoprenylcysteine O-methyltransferase
- cAMP response element binding protein binding
- C-terminal protein carboxyl methyltransferase
- enzyme
- protein binding
- Isoprenylcysteine carboxyl methyltransferase (ICMT) family
Pathways
Biological processes and signaling networks where the Icmt gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cervical cancer
- metastasis
- epithelial uterine cancer
- tumorigenesis
- abdominal aortic aneurysm
- developmental delay
- cervical small cell carcinoma
- extrapulmonary small cell cancer
role in cell
- growth
- cell viability
- apoptosis
- cell death
- response
- proliferation
- migration
- colony formation
- self-renewal
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- ribosome
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Icmt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- S-adenosylhomocysteine metabolic process
- C-terminal protein methylation
- S-adenosylmethioninamine metabolic process
- protein targeting to membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
- protein C-terminal carboxyl O-methyltransferase activity