Mlip Gene Summary [Mouse]
Enables lamin binding activity and transcription corepressor activity. Involved in negative regulation of cardiac muscle hypertrophy in response to stress. Acts upstream of or within negative regulation of cardiac muscle hypertrophy and negative regulation of transcription by RNA polymerase II. Located in PML body; nuclear envelope; and sarcolemma. Is expressed in frontal suture frontal osteogenic front. Orthologous to human MLIP (muscular LMNA interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Mlip |
| Official Name | muscular LMNA-interacting protein [Source:MGI Symbol;Acc:MGI:1916892] |
| Ensembl ID | ENSMUSG00000032355 |
| Bio databases IDs | |
| Aliases | muscular LMNA-interacting protein |
| Synonyms | 2310046A06Rik, AI931782, C6orf142, CIP, LOC652745, LOC691933, MMCKR, muscular LMNA-interacting protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mlip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-repressor
- lamin binding
- protein binding
- Muscular LMNA-interacting protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- hepatitis B
- breast cancer
- myopathy with myalgia, increased serum creatine kinase, and episodic rhabdomyolysis
- autosomal dominant mental retardation type 64
- oral submucous fibrosis
- myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis
- muscular dystrophy
- attention deficit hyperactivity disorder
- heart failure
regulated by
- SUPT16H
role in cell
- clustering
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- nuclear envelope
- sarcolemma
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mlip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of cardiac muscle hypertrophy
- transcription from RNA polymerase II promoter
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nuclear envelope
- nucleus
- PML body
- sarcolemma
- nuclear lumen
- cytosol
Molecular Function
What the gene product does at the molecular level
- transcription corepressor activity
- lamin binding