Csrnp1 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including face morphogenesis; platelet-derived growth factor receptor signaling pathway; and roof of mouth development. Located in nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human CSRNP1 (cysteine and serine rich nuclear protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Csrnp1 |
| Official Name | cysteine-serine-rich nuclear protein 1 [Source:MGI Symbol;Acc:MGI:2387989] |
| Ensembl ID | ENSMUSG00000032515 |
| Bio databases IDs | |
| Aliases | cysteine-serine-rich nuclear protein 1 |
| Synonyms | 4931429D10Rik, AXUD1, cysteine and serine rich nuclear protein 1, cysteine-serine-rich nuclear protein 1, FAM130B, TAIP-3, URAX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Csrnp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- Cysteine/serine-rich nuclear protein N-terminus
- protein binding
- sequence-specific DNA binding
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase II
disease
- COVID-19
- chronic lymphocytic leukemia
- diabetic nephropathy
- chronic periodontal disease
- oligoarticular juvenile idiopathic arthritis
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Csrnp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- post-embryonic development
- apoptotic process
- palate development
- platelet-derived growth factor receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- skeletal system morphogenesis
- face morphogenesis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity