Sertad2 Gene Summary [Mouse]
Enables transcription coactivator activity. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; nervous system; and sensory organ. Orthologous to human SERTAD2 (SERTA domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Sertad2 |
| Official Name | SERTA domain containing 2 [Source:MGI Symbol;Acc:MGI:1931026] |
| Ensembl ID | ENSMUSG00000049800 |
| Bio databases IDs | |
| Aliases | SERTA domain containing 2 |
| Synonyms | KIAA0127, mKIAA0127, MNCb-1504, SEI-2, SERTA domain containing 2, TRIP-Br2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sertad2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nuclear export signal
- transcription co-activator
- SERTA motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- obesity
- bipolar disorder
- chronic obstructive pulmonary disease
- metastatic colorectal cancer
- hemorrhoid
role in cell
- expression in
- proliferation
- growth
- metabolism in
- lipolysis in
- thermogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sertad2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity