NDN Gene Summary [Human]
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic neurons. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NDN |
| Official Name | necdin, MAGE family member [Source:HGNC Symbol;Acc:HGNC:7675] |
| Ensembl ID | ENSG00000182636 |
| Bio databases IDs | |
| Aliases | necdin, MAGE family member, Prader-Willi syndrome chromosome region |
| Synonyms | AC270095.2, HsT16328, NECDIN, necdin, MAGE family member, Peg6, PWCR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NDN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- gamma-tubulin binding
- transcription regulator
- MAGE homology domain
- necdin homology domain
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous cell lung cancer
- lung squamous cell carcinoma
- schizophrenia
- lung adenocarcinoma
- lung adenocarcinoma formation
- colorectal adenoma
- colorectal adenoma formation
- endometrial cancer
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
role in cell
- migration
- proliferation
- apoptosis
- growth
- colony formation
- formation
- differentiation
- activation
- outgrowth
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- mitochondrial fraction
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- growth cone
- cellular protrusions
- membrane processes
- perikaryon
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NDN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein deacetylation
- post-embryonic development
- positive regulation of transcription from RNA polymerase II promoter
- glial cell migration
- axonal fasciculation
- negative regulation of transcription from RNA polymerase II promoter
- respiratory system process
- nerve growth factor receptor signaling pathway
- neuron migration
- central nervous system development
- axon extension
- multicellular organismal homeostasis
- sensory perception of pain
- genetic imprinting
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytosol
- macromolecular complex
- perikaryon
- cell projection
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- gamma-tubulin binding