Alg3 Gene Summary [Mouse]
Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Orthologous to human ALG3 (ALG3 alpha-1,3- mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Alg3 |
| Official Name | asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase) [Source:MGI Symbol;Acc:MGI:1098592] |
| Ensembl ID | ENSMUSG00000033809 |
| Bio databases IDs | |
| Aliases | asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase) |
| Synonyms | ALG3 alpha-1,3- mannosyltransferase, ALG3, alpha-1,3- mannosyltransferase, ALG3 α-1,3- mannosyltransferase, ALG3, α-1,3- mannosyltransferase, CDG1D, CDGS4, CDGS6, D16Ertd36e, not, Not56, NOT56L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Alg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-1,3-mannosyltransferase
- enzyme
- protein binding
- ALG3 protein
- Dol-P-Man:Man5GlcNAc2-PP-Dol α-1,3-mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- HER2 negative hormone receptor negative breast cancer
- congenital disorder of glycosylation type 1d
- hereditary disorder
- organismal death
- cutaneous melanoma
- cutaneous melanoma cancer
- ovarian cancer
- mental retardation
- congenital disorders of glycosylation
role in cell
- expression in
- cellular infiltration by
- proliferation
- binding in
- sphere formation by
- dipeptide repeat protein sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Alg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein glycosylation
- protein N-linked glycosylation
- dolichol-linked oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- alpha-1,3-mannosyltransferase activity
- protein binding
- dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity