Gpr21 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor activity. Acts upstream of or within glucose homeostasis; negative regulation of insulin receptor signaling pathway; and regulation of growth. Predicted to be active in plasma membrane. Is expressed in cerebral cortex; cerebral cortex marginal layer; cerebral cortex subventricular zone; and cortical plate. Orthologous to human GPR21 (G protein-coupled receptor 21). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Gpr21 |
| Official Name | G protein-coupled receptor 21 [Source:MGI Symbol;Acc:MGI:2441890] |
| Ensembl ID | ENSMUSG00000053164 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 21 |
| Synonyms | C230004C13Rik, G protein-coupled receptor 21, LOC681885 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- insulin receptor signaling pathway
- glucose homeostasis
- negative regulation of insulin receptor signaling pathway
- positive regulation of multicellular organism growth
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity