B3galt2 Gene Summary [Mouse]
Enables N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity. Acts upstream of or within oligosaccharide biosynthetic process. Predicted to be active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; male reproductive gland or organ; respiratory system; and sensory organ. Orthologous to human B3GALT2 (beta-1,3-galactosyltransferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | B3galt2 |
| Official Name | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 [Source:MGI Symbol;Acc:MGI:1349461] |
| Ensembl ID | ENSMUSG00000033849 |
| Bio databases IDs | |
| Aliases | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 |
| Synonyms | Beta-1,3-galactosyltransferase 2, BETA3GALT2, GLCT2, LOC683527, UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2, UDP-Gal:betaGlcNAc β 1,3-galactosyltransferase, polypeptide 2, β-1,3-galactosyltransferase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse B3galt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta-1,3-galactosyltransferase 2 N-terminus
- UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase
- galactosyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- nonalcoholic fatty liver disease
- gout
- infarction
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- neurological disorder
- Cornelia de Lange syndrome
role in cell
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse B3galt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- protein glycosylation
- galactosylceramide biosynthetic process
- oligosaccharide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity
- UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity