Chmp2a Gene Summary [Mouse]
Predicted to enable phosphatidylcholine binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including mitotic nuclear division; regulation of cell cycle process; and vacuolar transport. Located in cytosol. Is expressed in several structures, including branchial arch; facial prominence; ganglia; gut; and limb bud. Orthologous to human CHMP2A (charged multivesicular body protein 2A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chmp2a |
| Official Name | charged multivesicular body protein 2A [Source:MGI Symbol;Acc:MGI:1916203] |
| Ensembl ID | ENSMUSG00000033916 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 2A |
| Synonyms | 1500016L11Rik, BC-2, charged multivesicular body protein 2A, CHMP2, mVps2, RGD1305050, VPS2, VPS2A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chmp2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- binding protein
- protein domain specific binding
- protein binding
- Snf7
Pathways
Biological processes and signaling networks where the Chmp2a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
role in cell
- accumulation in
- aggregation in
- production in
- autophagy by
- fusion
- damage
- quantity
- biogenesis in
- molecular cleavage in
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cellular membrane
- Plasma Membrane
- vesicles
- contractile rings
- midbody
- cytosol
- lysosome membrane
- nuclear pores
- nuclear envelope
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- kinetochores
- chromatin
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chmp2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- late endosome to vacuole transport
- protein homooligomerization
- nucleus organization
- establishment of protein localization
- protein polymerization
- regulation of centrosome duplication
- non-lytic virus budding from plasma membrane
- release of virus from host
- plasma membrane repair
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- autophagy
- endosome transport via multivesicular body sorting pathway
- multivesicular body sorting pathway
- membrane invagination
- exit from mitosis
- nuclear envelope reassembly
- mitotic metaphase plate congression
- macroautophagy
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- chromatin
- lysosomal membrane
- autophagic vacuole membrane
- plasma membrane
- nuclear pore
- nuclear envelope
- membrane coat
- extracellular vesicular exosome
- kinetochore microtubule
- membrane
- cytosol
- midbody
- multivesicular body membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- phosphatidylcholine binding