Vps37a Gene Summary [Mouse]
Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in centrosome; cytosol; and nucleoplasm. Predicted to be part of ESCRT I complex. Is expressed in several structures, including branchial arch; facial prominence; heart; limb bud; and neural fold. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 53. Orthologous to human VPS37A (VPS37A subunit of ESCRT-I). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Vps37a |
| Official Name | vacuolar protein sorting 37A [Source:MGI Symbol;Acc:MGI:1261835] |
| Ensembl ID | ENSMUSG00000031600 |
| Bio databases IDs | |
| Aliases | vacuolar protein sorting 37A |
| Synonyms | 2210018P21Rik, 4930592A21Rik, D8Ertd531e, FLJ32642, HCRP1, PQBP2, SPG53, vacuolar protein sorting 37A, VPS37A subunit of ESCRT-I |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps37a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Modifier of rudimentary (Mod(r)) protein
- protein binding
Pathways
Biological processes and signaling networks where the Vps37a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- paralysis
- autosomal recessive spastic paraplegia type 53
role in cell
- migration
- invasion by
- phosphorylation in
- transcription in
- activation in
- cell death
- proliferation
- signaling in
- degradation in
- closure in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- centrosome
- cytosol
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps37a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- protein targeting to vacuole
- protein targeting to membrane
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- centrosome
- intracellular membrane-bounded organelle
- ESCRT I complex
- cytosol
- endosome membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding