Loxl2 Gene Summary [Mouse]
Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Involved in negative regulation of stem cell population maintenance; positive regulation of chondrocyte differentiation; and response to hypoxia. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in brain; chondrocranium; renal cortical interstitium; and visceral epithelium of mature renal corpuscle. Orthologous to human LOXL2 (lysyl oxidase like 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Loxl2 |
| Official Name | lysyl oxidase-like 2 [Source:MGI Symbol;Acc:MGI:2137913] |
| Ensembl ID | ENSMUSG00000034205 |
| Bio databases IDs | |
| Aliases | lysyl oxidase-like 2 |
| Synonyms | 1110004B06Rik, 4930526G11Rik, 9430067E15Rik, LOC100047339, LOC675778, lysyl oxidase-like 2 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Loxl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- copper ion binding
- protein-lysine 6-oxidase
- calcium ion binding
- enzyme
- Lysyl oxidase
- carbohydrate binding
- Scavenger receptor Cys-rich
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cyanosis
- bleomycin-induced pulmonary fibrosis
role in cell
- expression in
- differentiation
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Extracellular Space
- Endoplasmic Reticulum
- nucleoplasm
- chromatin
- pericentric heterochromatin
- basement membrane