Kif4 Gene Summary [Mouse]
Predicted to enable microtubule motor activity. Predicted to be involved in mitotic cytokinesis and mitotic spindle midzone assembly. Predicted to be located in midbody and nucleoplasm. Predicted to be part of microtubule associated complex. Is expressed in several structures, including alimentary system; brain; extraembryonic component; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 100. Orthologous to several human genes including KIF4A (kinesin family member 4A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kif4 |
| Official Name | kinesin family member 4 [Source:MGI Symbol;Acc:MGI:108389] |
| Ensembl ID | ENSMUSG00000034311 |
| Bio databases IDs | |
| Aliases | kinesin family member 4 |
| Synonyms | D330050K22Rik, KIF4, KIF4G1, kinesin family member 4, kinesin family member 4A, Kns4, MRX100, TMDI, XLID100 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kif4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin motor, catalytic domain
- microtubule binding
- Myosin and Kinesin motor domain
- Synaptonemal complex protein 1 (SCP-1)
- Kinesin motor domain
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- protein binding
- microtubule motor protein
- HOOK protein coiled-coil region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- metastasis
- primary breast cancer
- X-linked mental retardation type 100
- non-small cell lung cancer
- mammary neoplasm
- non-small cell lung carcinoma
- survival
- urothelial bladder carcinoma
role in cell
- expression in
- phosphorylation in
- proliferation
- growth
- quantity
- apoptosis
- degradation in
- production in
- formation
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- microtubule aster fraction
- Cytoplasm
- contractile rings
- midbody
- cytosol
- chromosome
- nucleoplasm
- spindle fibers
- nuclear matrix
- growth cone
- central spindle
- mitotic spindle
- chromosomal arms
- perikaryon
- axons
- plasma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kif4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle midzone assembly involved in mitosis
- anterograde axon cargo transport
- spindle elongation
- cytokinesis after mitosis
- mitotic spindle organization
- organelle organization
Cellular Component
Where in the cell the gene product is active
- spindle microtubule
- cytoplasm
- membrane
- cytosol
- nuclear matrix
- midbody
- chromosome
- microtubule associated complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- ATP binding
- microtubule motor activity
- protein binding
- metal ion binding
- iron-sulfur cluster binding
- microtubule binding