HMGXB4 Gene Summary [Human]
High mobility group (HMG) proteins are nonhistone chromosomal proteins. See HMG2 (MIM 163906) for additional information on HMG proteins.[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | HMGXB4 |
| Official Name | HMG-box containing 4 [Source:HGNC Symbol;Acc:HGNC:5003] |
| Ensembl ID | ENSG00000100281 |
| Bio databases IDs | |
| Aliases | HMG-box containing 4 |
| Synonyms | 4733401K04Rik, HMG2L1, Hmgb2l1, HMGBCG, HMG-box containing 4, HMG box domain containing 4, P53N, THC211630 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HMGXB4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- high mobility group (HMG)-box domain superfamily
- HMG (high mobility group) box
- high mobility group
- Domain of unknown function (DUF4171)
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- endotoxin shock response
- acute lung injury
regulated by
- lipopolysaccharide
- WNT3A
- (R)-3-hydroxybutyric acid
- topotecan
- garcinol
role in cell
- expression in
- production in
- cell-cell adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HMGXB4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Wnt receptor signaling pathway
- endosome to lysosome transport
- negative regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- NURF complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding