Gnb4 Gene Summary [Mouse]
Predicted to enable GTPase activity and signaling receptor complex adaptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in myelin sheath. Part of heterotrimeric G-protein complex. Is active in synapse. Is expressed in several structures, including clavicle; eye; genitourinary system; heart valve; and nervous system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate F. Orthologous to human GNB4 (G protein subunit beta 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gnb4 |
| Official Name | guanine nucleotide binding protein (G protein), beta 4 [Source:MGI Symbol;Acc:MGI:104581] |
| Ensembl ID | ENSMUSG00000027669 |
| Bio databases IDs | |
| Aliases | guanine nucleotide binding protein (G protein), beta 4 |
| Synonyms | 6720453A21RIK, CMTD1F, Gb4, GBB4, G(beta)4, G protein beta 4, G protein subunit beta 4, G protein subunit β 4, G protein β 4, guanine nucleotide binding protein (G protein), beta 4, guanine nucleotide binding protein (G protein), β 4, G(β)4, HG2B, LOC103691541, LOC107986157 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gnb4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- WD domain, G-beta repeat
- GTPase
- WD40
- protein binding
Pathways
Biological processes and signaling networks where the Gnb4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- Gαs Signaling
- IL-1 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Phospholipase C Signaling
- Protein Kinase A Signaling
- RhoGDI Signaling
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adenoma formation
- Charcot-Marie-Tooth disease dominant intermediate type F
- gastric cancer
- organismal death
- metastasis
- Charcot-Marie-Tooth disease
- Alzheimer disease
- atrial fibrillation
- pituitary gland adenoma
role in cell
- proliferation
- activation in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cytosol
- synapse
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gnb4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- substantia nigra development
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- heterotrimeric G-protein complex
- cytoplasm
- cell body
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor signaling complex scaffold activity