Ric8a Gene Summary [Mouse]
Enables G-protein alpha-subunit binding activity and protein folding chaperone. Involved in G protein-coupled receptor signaling pathway. Acts upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Located in membrane. Is active in plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; female reproductive system; nervous system; and sensory organ. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ric8a |
| Official Name | RIC8 guanine nucleotide exchange factor A [Source:MGI Symbol;Acc:MGI:2141866] |
| Ensembl ID | ENSMUSG00000025485 |
| Bio databases IDs | |
| Aliases | RIC8 guanine nucleotide exchange factor A |
| Synonyms | AI114950, RIC-8, RIC8 guanine nucleotide exchange factor A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ric8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanyl-nucleotide exchange factor
- GTPase activator
- protein binding
- Guanine nucleotide exchange factor synembryn
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cataract
- uterine leiomyoma
- leiomyomatosis
- hypoplasia
- myocardial infarction
role in cell
- phosphorylation in
- expression in
- movement
- movement in
- migration
- organization
- cohesion
- binding in
- cohesion in
- cytokinesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cell cortex
- Nucleus
- Plasma Membrane
- centrosome
- midbody
- cytosol
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ric8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway
- in utero embryonic development
- cell migration involved in gastrulation
- vasculature development
- basement membrane organization
- cell-cell adhesion involved in gastrulation
- visual learning
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein alpha-subunit binding
- guanyl-nucleotide exchange factor activity