Atad3a

Predicted to enable ATP hydrolysis activity; identical protein binding activity; and protein serine/threonine kinase inhibitor activity. Predicted to be involved in several processes, including antiviral innate immune response; mitochondrion organization; and negative regulation of PERK-mediated unfolded protein response. Located in mitochondrion. Is expressed in several structures, including brain; femur; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in Harel-Yoon syndrome and neonatal lethal pontocerebellar hypoplasia, hypotonia, and respiratory insufficiency syndrome. Orthologous to several human genes including ATAD3A (ATPase family AAA domain containing 3A). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atad3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.