Ccdc186 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Acts upstream of or within insulin secretion involved in cellular response to glucose stimulus; response to bacterium; and vesicle cytoskeletal trafficking. Located in Golgi apparatus. Is expressed in several structures, including gut; heart; liver; lung; and metanephros. Orthologous to human CCDC186 (coiled-coil domain containing 186). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccdc186 |
| Official Name | coiled-coil domain containing 186 [Source:MGI Symbol;Acc:MGI:2445022] |
| Ensembl ID | ENSMUSG00000035173 |
| Bio databases IDs | |
| Aliases | coiled-coil domain containing 186 |
| Synonyms | 1810028B20Rik, A630007B06Rik, C10orf118, CCCP-1, coiled-coil domain containing 186, FLJ10188, golgin104, Otg1, RGD1307158 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccdc186 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chromosome segregation protein SMC, primarily archaeal type
- Synaptonemal complex protein 1 (SCP-1)
- Septation ring formation regulator, EzrA
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccdc186 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to bacterium
- insulin secretion involved in cellular response to glucose stimulus
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
Molecular Function
What the gene product does at the molecular level
- small GTPase binding