Nkx6-1 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including endocrine pancreas development; regulation of oligodendrocyte differentiation; and spinal cord motor neuron cell fate specification. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; gut; and trachea. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nkx6-1 |
| Official Name | NK6 homeobox 1 [Source:MGI Symbol;Acc:MGI:1206039] |
| Ensembl ID | ENSMUSG00000035187 |
| Bio databases IDs | |
| Aliases | NK6 homeobox 1 |
| Synonyms | NK6 homeobox 1, NKX6.1, NKX6A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nkx6-1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- chromatin binding
- transcription factor binding
- sequence-specific DNA binding
- negative regulation of DNA-binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- homeodomain
- transcription factor activity
- TN domain
Pathways
Biological processes and signaling networks where the Nkx6-1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- motor dysfunction or movement disorder
- paralysis
role in cell
- number
- expression in
- quantity
- proliferation
- regeneration
- development
- migration
- differentiation
- extension
- conversion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nkx6-1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- positive regulation of neuron differentiation
- central nervous system neuron differentiation
- response to xenobiotic stimulus
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- pancreatic A cell differentiation
- negative regulation of oligodendrocyte differentiation
- positive regulation of oligodendrocyte differentiation
- negative regulation of transcription from RNA polymerase II promoter
- type B pancreatic cell maturation
- type B pancreatic cell proliferation
- cellular response to peptide hormone stimulus
- positive regulation of type B pancreatic cell development
- positive regulation of insulin secretion
- glucose mediated signaling pathway
- regulation of neuron migration
- pancreas development
- oligodendrocyte differentiation
- smoothened signaling pathway
- response to nicotine
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
- regulation of axon extension
- cell differentiation
- cellular response to cytokine stimulus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- chromatin
Molecular Function
What the gene product does at the molecular level
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity