Cops8

Predicted to be involved in activation of NF-kappaB-inducing kinase activity; negative regulation of cell population proliferation; and protein modification process. Located in nucleus. Part of COP9 signalosome. Is expressed in several structures, including early embryo; liver; and oocyte. Orthologous to human COPS8 (COP9 signalosome subunit 8). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cops8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Cops8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cops8 gene, providing context for its role in the cell.