Ccl12

Enables CCR2 chemokine receptor binding activity. Involved in angiogenesis; inflammatory response; and monocyte chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in several diseases, including IgA vasculitis; aggressive periodontitis; autoimmune disease (multiple); end stage renal disease; and gastrointestinal system cancer (multiple). Orthologous to several human genes including CCL2 (C-C motif chemokine ligand 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccl12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ccl12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.