Slc11a2 Gene Summary [Mouse]
Enables cobalt ion transmembrane transporter activity. Acts upstream of or within several processes, including erythrocyte development; multicellular organismal-level iron ion homeostasis; and transition metal ion transport. Located in brush border membrane; endosome; and extracellular vesicle. Is expressed in several structures, including intestine; liver; reproductive system; spleen; and yolk sac. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc11a2 |
| Official Name | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 [Source:MGI Symbol;Acc:MGI:1345279] |
| Ensembl ID | ENSMUSG00000023030 |
| Bio databases IDs | |
| Aliases | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 |
| Synonyms | AHMIO1, DCT1, DMT1, Dmt1 (containing IRE), mk, NRAMP2, solute carrier family 11 member 2, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2, van |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc11a2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Natural resistance-associated macrophage protein
- iron ion binding
- cadmium ion binding
- ferrous iron transporter
- copper ion binding
- zinc ion binding
- YLL motif
- nickel ion binding
- transition metal ion transporter
- lead ion transporter
- cobalt ion transporter
- iron ion transporter
- inorganic uptake permease
- protein binding
- zinc ion transporter
- vanadium ion transporter
- nickel ion transporter
- transition metal ion binding
- copper ion transporter
- binding protein
- manganese ion transporter
- cadmium ion transporter
- cytosolic tail domain
- Solute carrier families 5 and 6-like; solute binding domain
- manganese ion binding
- solute:hydrogen symporter
- transporter
Pathways
Biological processes and signaling networks where the Slc11a2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- hypochromic microcytic anemia with iron overload 1
- Parkinson disease
- growth failure
- iron deficiency
- anisocytosis
- poikilocytosis
- microcytic anemia
- gestational diabetes mellitus
role in cell
- expression in
- cell viability
- fragmentation
- cell death
- development
- morphogenesis
- abnormal morphology
- tubulation
- number
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- membrane fraction
- extracellular vesicles
- Cytoplasm
- cell surface
- apical compartment
- basal compartment
- perinuclear region
- cellular membrane
- Nucleus
- vacuole
- endosomes
- vesicles
- lysosome
- Endoplasmic Reticulum
- Mitochondria
- apical membrane
- trans Golgi network
- lysosome membrane
- endosomal membrane
- recycling endosomes
- early endosomes
- late endosomes
- cytoplasmic vesicles
- brush border
- brush border membrane vesicles
- phagosomes
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc11a2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- lead ion transport
- heme biosynthetic process
- erythrocyte development
- dendrite morphogenesis
- learning or memory
- cobalt ion transport
- cellular iron ion homeostasis
- copper ion transport
- manganese ion transport
- manganese ion transmembrane transport
- cadmium ion transmembrane transport
- iron ion transport
- response to iron ion
- iron assimilation
- nickel cation transmembrane transport
- copper ion transmembrane transport
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- paraferritin complex
- Golgi apparatus
- mitochondrial outer membrane
- vacuole
- plasma membrane
- lysosomal membrane
- early endosome membrane
- late endosome membrane
- nucleus
- early endosome
- brush border membrane
- perinuclear region of cytoplasm
- apical part of cell
- basal part of cell
- cytoplasm
- membrane
- mitochondrion
- cytoplasmic vesicle
- endosome membrane
- recycling endosome
- recycling endosome membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- transition metal ion transmembrane transporter activity
- iron ion transmembrane transporter activity
- nickel cation transmembrane transporter activity
- cobalt ion transmembrane transporter activity
- cadmium ion transmembrane transporter activity
- solute:hydrogen symporter activity
- manganese ion transmembrane transporter activity
- lead ion transmembrane transporter activity
- copper ion transmembrane transporter activity
- ferrous iron transmembrane transporter activity
- protein binding
- cadmium ion binding