Usp35 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP35 (ubiquitin specific peptidase 35). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp35 |
| Official Name | ubiquitin specific peptidase 35 [Source:MGI Symbol;Acc:MGI:2685339] |
| Ensembl ID | ENSMUSG00000035713 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 35 |
| Synonyms | Gm1088, Gm493, RGD1565984, ubiquitin specific peptidase 35 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Usp35 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- estrogen receptor positive breast cancer
- neuroticism
- organismal death
- luminal A breast cancer
- luminal B breast cancer
regulated by
- beta-estradiol
- AKT
- MK2206
- mir-140
- mir-26 (includes others)
- UHRF1
role in cell
- activation in
- expression in
- growth
- binding in
- fulvestrant sensitivity
- tamoxifen resistance
- fulvestrant resistance
- deubiquitination in
- tamoxifen sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity