Gsx2 Gene Summary [Mouse]
Enables DNA binding activity. Involved in generation of neurons and olfactory bulb development. Acts upstream of or within several processes, including nervous system development; positive regulation of Notch signaling pathway; and positive regulation of oligodendrocyte differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; future midbrain; and genitourinary system. Orthologous to human GSX2 (GS homeobox 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gsx2 |
| Official Name | GS homeobox 2 [Source:MGI Symbol;Acc:MGI:95843] |
| Ensembl ID | ENSMUSG00000035946 |
| Bio databases IDs | |
| Aliases | GS homeobox 2 |
| Synonyms | DMJDS2, GSH2, GS homeobox 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gsx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
Pathways
Biological processes and signaling networks where the Gsx2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- schizophrenia
- diencephalic-mesencephalic junction dysplasia syndrome 2
- hypoxia
- apnea
- cyanosis
role in cell
- differentiation
- growth
- quantity
- migration
- development
- abnormal morphology
- generation
- patterning
- self-renewal
- fate determination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gsx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- olfactory bulb interneuron differentiation
- telencephalon regionalization
- spinal cord association neuron differentiation
- subpallium neuron fate commitment
- forebrain dorsal/ventral pattern formation
- forebrain morphogenesis
- regulation of respiratory gaseous exchange by neurological system process
- positive regulation of Notch signaling pathway
- hindbrain morphogenesis
- regulation of transcription from RNA polymerase II promoter
- positive regulation of oligodendrocyte differentiation
- GABAergic neuron differentiation
- Notch signaling pathway
- neuron fate specification
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding RNA polymerase II transcription factor activity