Phactr4 Gene Summary [Mouse]
Enables actin binding activity; protein phosphatase 1 binding activity; and protein phosphatase activator activity. Involved in several processes, including enteric nervous system development; morphogenesis of embryonic epithelium; and negative regulation of integrin-mediated signaling pathway. Located in lamellipodium. Is expressed in several structures, including 1st branchial arch mandibular component; central nervous system; facial prominence; and sensory organ. Orthologous to human PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phactr4 |
| Official Name | phosphatase and actin regulator 4 [Source:MGI Symbol;Acc:MGI:2140327] |
| Ensembl ID | ENSMUSG00000066043 |
| Bio databases IDs | |
| Aliases | phosphatase and actin regulator 4 |
| Synonyms | 3110001B12RIK, C330013F19Rik, mKIAA4120, phosphatase and actin regulator 4, PPP1R124 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phactr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RPEL repeat
- protein phosphatase 1 binding
- actin binding
- protein phosphatase regulator
- phosphatase activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phactr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- closure of optic fissure
- enteric nervous system development
- neural crest cell migration
- neural tube closure
- positive regulation of catalytic activity
- regulation of cell cycle
- Rho protein signal transduction
- negative regulation of integrin-mediated signaling pathway
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin binding
- protein phosphatase activator activity
- protein phosphatase 1 binding