Copg1 Gene Summary [Mouse]
Predicted to enable structural molecule activity. Predicted to be involved in several processes, including Golgi vesicle transport; establishment of Golgi localization; and organelle transport along microtubule. Located in Golgi membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Used to study combined immunodeficiency and polyclonal hypergammaglobulinemia. Human ortholog(s) of this gene implicated in immunodeficiency 128. Orthologous to human COPG1 (COPI coat complex subunit gamma 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Copg1 |
| Official Name | coatomer protein complex, subunit gamma 1 [Source:MGI Symbol;Acc:MGI:1858696] |
| Ensembl ID | ENSMUSG00000030058 |
| Bio databases IDs | |
| Aliases | coatomer protein complex, subunit gamma 1 |
| Synonyms | coatomer protein complex, subunit gamma 1, coatomer protein complex, subunit γ 1, COPG, COPGAMMA1, COPI coat complex subunit gamma 1, COPI coat complex subunit γ 1, D6Ertd71e, D6Wsu16e, IMD128, IPI00001890 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Copg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coatomer gamma subunit appendage platform subdomain
- Coatomer subunit gamma-1 C-terminal appendage platform
- protein binding
- Adaptin N terminal region
- HEAT repeats
- transporter
Pathways
Biological processes and signaling networks where the Copg1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- non-insulin-dependent diabetes mellitus
- infection by lymphocytic choriomeningitis virus
- infection by Human parainfluenza virus 3
- infection by vesicular stomatitis virus
role in cell
- cell death
- activation in
- replication in
- binding in
- accumulation in
- transformation
- viral entry
- endoplasmic reticulum-associated degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi Apparatus
- ER-to-Golgi intermediate compartment
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- transport vesicles
- cis Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Copg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- organelle transport along microtubule
- ER to Golgi vesicle-mediated transport
- establishment of Golgi localization
- intra-Golgi vesicle-mediated transport
- intracellular protein transport
- protein secretion
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- Golgi apparatus
- Golgi membrane
- endoplasmic reticulum
- transport vesicle
- endoplasmic reticulum-Golgi intermediate compartment
- COPI vesicle coat
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity