Oxsr1 Gene Summary [Mouse]
Enables protein serine/threonine kinase activity. Involved in several processes, including cellular hypotonic response; chemokine (C-C motif) ligand 21 signaling pathway; and positive regulation of T cell chemotaxis. Predicted to be active in cytosol. Is expressed in loop of Henle distal straight tubule and metanephros. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Oxsr1 |
| Official Name | oxidative-stress responsive 1 [Source:MGI Symbol;Acc:MGI:1917378] |
| Ensembl ID | ENSMUSG00000036737 |
| Bio databases IDs | |
| Aliases | oxidative-stress responsive 1 |
| Synonyms | 2210022N24Rik, 2810422B09Rik, mKIAA1101, OSR1, OXIDATIVE STRESS RESPONSIVE 1, oxidative stress responsive kinase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Oxsr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- channel regulator
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- ATP binding
- protein binding
- magnesium ion binding
- Protein kinase domain
- identical protein binding
- potassium channel inhibitor
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- ion channel binding
- Oxidative-stress-responsive kinase 1 C-terminal domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypercalciuria
- organismal death
- hypotension
- metastasis
- breast cancer
- hypokalemia
role in cell
- expression in
- replication in
- migration
- epithelial-mesenchymal transition in
- signal transduction in
- volume
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- Cytoplasm
- cilia
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Oxsr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chemokine (C-X-C motif) ligand 12 signaling pathway
- chemokine (C-C motif) ligand 21 signaling pathway
- signal transduction
- osmosensory signaling pathway
- protein autophosphorylation
- response to xenobiotic stimulus
- protein phosphorylation
- cell volume homeostasis
- renal sodium ion absorption
- response to oxidative stress
- cellular hypotonic response
- cellular hyperosmotic response
- positive regulation of T cell chemotaxis
- intracellular signal transduction
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein kinase binding
- identical protein binding
- protein binding
- protein serine/threonine kinase activity