Pkn1 Gene Summary [Mouse]
Enables protein kinase activity. Acts upstream of or within several processes, including negative regulation of B cell proliferation; regulation of macromolecule metabolic process; and spleen development. Located in cytoplasmic vesicle. Is expressed in several structures, including brown fat; genitourinary system; gut; nervous system; and vascular system. Orthologous to human PKN1 (protein kinase N1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pkn1 |
| Official Name | protein kinase N1 [Source:MGI Symbol;Acc:MGI:108022] |
| Ensembl ID | ENSMUSG00000057672 |
| Bio databases IDs | |
| Aliases | protein kinase N1 |
| Synonyms | DBK, F730027O18Rik, PAK-1, PKN, PKN-ALPHA, PKN-α, PRK1, PRKCL1, protein kinase N1, Stk3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pkn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- p21 binding domain
- protein serine/threonine kinase
- protein kinase
- transcription co-activator
- RhoA binding domain
- regulatory domain
- ATP-binding domain
- androgen receptor binding
- leucine zipper domain
- chromatin binding
- enzyme
- Protein kinase domain
- activation loop
- Extension to Ser/Thr-type protein kinases
- alcohol group acceptor phosphotransferase
- protein kinase C
- Tyrosine kinase, catalytic domain
- Hr1 repeat
- C2 domain
- HR1
- histone binding
- Protein kinase (unclassified specificity)
- autoinhibitory protein domain
- Protein kinase C terminal domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein kinase C binding
- enzyme binding
- histone deacetylase binding
- protein binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Rho-binding domain
Pathways
Biological processes and signaling networks where the Pkn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- hyperplasia
- androgenic alopecia
- urolithiasis
- glomerulonephritis
- ureterolithiasis
- glioma
- glioma formation
- chronic fatigue syndrome
- pancreatic carcinoma
phenotypes
- abnormal behavior
- decreased eosinophil cell number
- decreased large unstained cell number
- decreased leukocyte cell number
- decreased lymphocyte cell number
- decreased monocyte cell number
- decreased neutrophil cell number
- decreased red blood cell distribution width
- hypoactivity
- increased anxiety-related response
- increased hemoglobin content
- increased thigmotaxis
- increased total body fat amount
- abnormal calcium ion homeostasis
- abnormal cardiovascular system physiology
- abnormal germinal center B cell physiology
- abnormal heart echocardiography feature
- abnormal large unstained cell number
- abnormal leukocyte cell number
- abnormal lymphocyte cell number
- abnormal neutrophil cell number
- abnormal somatic hypermutation frequency
- decreased activation-induced B cell apoptosis
- decreased cardiac muscle contractility
- decreased cardiac muscle relaxation
- decreased left ventricle developed pressure
- decreased left ventricle systolic pressure
- glomerulonephritis
- increased B cell proliferation
- increased IgG1 level
- increased IgG2a level
- increased IgG2b level
- increased IgM level
- increased anti-double stranded DNA antibody level
- increased germinal center B cell number
- increased myocardial infarction size
- increased renal glomerulus basement membrane thickness
- increased spleen germinal center size
- increased splenocyte number
- mesangial cell hyperplasia
- renal glomerular immunoglobulin deposits
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- activation in
- migration
- cell viability
- growth
- invasion by
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal compartment
- ribosome
- Nucleus
- endosomes
- vesicles
- centrosome
- Endoplasmic Reticulum
- microtubules
- midbody
- cytosol
- nucleoplasm
- nuclear envelope
- spine apparatus
- synaptic vesicles
- cytoplasmic vesicles
- multivesicular bodies
- cleavage furrow
- axons
- Golgi vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pkn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- spleen development
- protein phosphorylation
- post-translational protein modification
- hyperosmotic response
- renal system process
- B cell homeostasis
- regulation of androgen receptor signaling pathway
- regulation of transcription from RNA polymerase II promoter
- B cell apoptotic process
- chromatin remodeling
- regulation of germinal center formation
- negative regulation of B cell proliferation
- positive regulation of transcription, DNA-dependent
- negative regulation of protein phosphorylation
- regulation of immunoglobulin production
- regulation of cell motility
- peptidyl-serine phosphorylation
- epithelial cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- cytoplasm
- cleavage furrow
- cytosol
- macromolecular complex
- midbody
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- histone deacetylase binding
- protein kinase activity
- chromatin binding
- protein serine/threonine kinase activity
- protein kinase C activity
- ATP binding
- protein binding
- androgen receptor binding
- histone binding
- ligand-dependent nuclear receptor transcription coactivator activity
- small GTPase binding
- histone kinase activity (H3-T11 specific)