Dner Gene Summary [Mouse]
Enables Notch binding activity. Acts upstream of or within Notch receptor processing; glial cell differentiation; and skeletal muscle fiber development. Located in dendrite and neuronal cell body. Is expressed in several structures, including alimentary system; central nervous system; limb; peripheral nervous system ganglion; and sensory organ. Orthologous to human DNER (delta/notch like EGF repeat containing). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dner |
| Official Name | delta/notch-like EGF repeat containing [Source:MGI Symbol;Acc:MGI:2152889] |
| Ensembl ID | ENSMUSG00000036766 |
| Bio databases IDs | |
| Aliases | delta/notch-like EGF repeat containing |
| Synonyms | A930026D19Rik, BET, Bret, delta/notch-like EGF repeat containing, UNQ26, δ/notch-like EGF repeat containing |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dner often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Human growth factor-like EGF
- clathrin binding
- protein binding
- Delta and Notch-like EGF-related receptor C-terminus
- transmembrane receptor
- EGF_CA
- notch binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- chronic obstructive pulmonary disease
- organismal death
- hepatocellular carcinoma
- epithelial cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- non-insulin-dependent diabetes mellitus
- cerebral amyloid angiopathy
- progesterone receptor-positive breast cancer
role in cell
- expression in
- apoptosis
- cell viability
- growth
- abnormal morphology
- doxorubicin sensitivity
- outgrowth
- quantity
- invasion by
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular compartment
- cell surface
- intracellular space
- perinuclear space
- dendritic trees
- early endosomes
- cytoplasmic vesicles
- perikaryon
- dendrites
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dner gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- synapse assembly
- central nervous system development
- Notch signaling pathway
- skeletal muscle fiber development
- Notch receptor processing
- endocytosis
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- dendrite
- early endosome
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- transmembrane signaling receptor activity
- protein binding
- calcium ion binding
- Notch binding
- clathrin binding