Pomk Gene Summary [Mouse]
Enables carbohydrate kinase activity. Involved in protein O-linked glycosylation. Acts upstream of or within several processes, including learning or memory; neuromuscular process; and sensory perception of pain. Is active in endoplasmic reticulum membrane. Is expressed in cerebral cortex. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A12 and muscular dystrophy-dystroglycanopathy type C12. Orthologous to human POMK (protein O-mannose kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pomk |
| Official Name | protein-O-mannose kinase [Source:MGI Symbol;Acc:MGI:1921903] |
| Ensembl ID | ENSMUSG00000037251 |
| Bio databases IDs | |
| Aliases | protein-O-mannose kinase |
| Synonyms | 4930444A02Rik, FLJ23356, MDDGA12, MDDGC12, protein-O-mannose kinase, RGD1310810, SGK196 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pomk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- carbohydrate kinase
- protein kinase
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies) type A12
- muscular dystrophy-dystroglycanopathy limb-girdle type C12
regulates
- carbohydrate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pomk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein O-linked glycosylation
- neuromuscular process
- sensory perception of pain
- brain development
- carbohydrate phosphorylation
- learning or memory
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- carbohydrate kinase activity
- protein kinase activity
- phosphotransferase activity, alcohol group as acceptor