Itih1 Gene Summary [Mouse]
This gene encodes a heavy chain of inter-alpha trypsin inhibitor (IaI) family of plasma serine protease inhibitors. IaI proteins are protein-glycosaminoglycan-protein complexes comprised of two heavy chains and a light chain. The encoded protein covalently associates with the light chain via a chondroitin sulfate moiety. Intravenous administration of the encoded protein improved survival of mice after infection with Escherichia coli. This gene is located adjacent to two other IaI heavy chain genes. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature protein. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | Itih1 |
| Official Name | inter-alpha trypsin inhibitor, heavy chain 1 [Source:MGI Symbol;Acc:MGI:96618] |
| Ensembl ID | ENSMUSG00000006529 |
| Bio databases IDs | |
| Aliases | inter-alpha trypsin inhibitor, heavy chain 1 |
| Synonyms | H1P, HC1, I alpha I HC1, IATIH, IGHEP1, inter-alpha trypsin inhibitor, heavy chain 1, inter-alpha-trypsin inhibitor heavy chain 1, inter-α trypsin inhibitor, heavy chain 1, inter-α-trypsin inhibitor heavy chain 1, Intin1, ITIH, ITI-HC1, I α I HC1, SHAP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Itih1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Inter-alpha-trypsin inhibitor heavy chain C-terminus
- Vault protein inter-alpha-trypsin domain
- von Willebrand factor (vWF) type A domain
- vWFA
- calcium ion binding
- von Willebrand factor type A domain
- protein binding
- carbohydrate binding
- hyaluronic acid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- hypertension
- anxiety disorder
- schizophrenia
- carpal tunnel syndrome
- bipolar disorder
- Parkinson disease
- hip or knee osteoarthritis
- open-angle glaucoma
- schizoaffective disorder
role in cell
- proliferation
- expression in
- apoptosis
- production in
- downregulation in
- phagocytosis
- cell spreading
- attachment
- phagocytosis by
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Itih1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hyaluronan metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding
- calcium ion binding
- hyaluronic acid binding
- carbohydrate binding