Bag4 Gene Summary [Mouse]
Predicted to enable adenyl-nucleotide exchange factor activity; protein-folding chaperone binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; regulation of actin filament organization; and regulation of phosphate metabolic process. Predicted to be located in plasma membrane. Predicted to be active in cytosol; membrane; and nucleus. Is expressed in foregut; heart ventricle; nose; pituitary gland; and urethra. Orthologous to human BAG4 (BAG cochaperone 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bag4 |
| Official Name | BCL2-associated athanogene 4 [Source:MGI Symbol;Acc:MGI:1914634] |
| Ensembl ID | ENSMUSG00000037316 |
| Bio databases IDs | |
| Aliases | BCL2-associated athanogene 4 |
| Synonyms | 2410112I15Rik, BAG cochaperone 4, BCL2-associated athanogene 4, SODD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bag4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- BAG domains, present in regulator of Hsp70 proteins
- binding protein
- glycine proline rich domain
- alpha helix
- BAG domain
- protein binding
- serine-proline rich domain
Pathways
Biological processes and signaling networks where the Bag4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung cancer
- hypoplasia
- breast cancer
- gout
- androgenic alopecia
- schizophrenia
- neoplastic cell transformation
role in cell
- expression in
- phosphorylation in
- apoptosis
- cell death
- proliferation
- migration
- S phase
- function
- quantity
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bag4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mRNA modification
- positive regulation of cell adhesion
- protein folding
- ruffle assembly
- positive regulation of stress fiber assembly
- negative regulation of apoptotic process
- cellular response to epidermal growth factor stimulus
- positive regulation of actin filament polymerization
- cellular response to tumor necrosis factor
- protein stabilization
- positive regulation of protein kinase B signaling cascade
- positive regulation of fibroblast migration
- protein localization in plasma membrane
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- RNA binding
- protein binding
- chaperone binding
- adenyl-nucleotide exchange factor activity