Med15 Gene Summary [Mouse]
Predicted to enable transcription coregulator activity. Acts upstream of or within somatic stem cell population maintenance. Predicted to be located in nucleoplasm. Predicted to be part of core mediator complex. Is expressed in several structures, including branchial arch; central nervous system; facial prominence; limb; and limb bud. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human MED15 (mediator complex subunit 15). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Med15 |
| Official Name | mediator complex subunit 15 [Source:MGI Symbol;Acc:MGI:2137379] |
| Ensembl ID | ENSMUSG00000012114 |
| Bio databases IDs | |
| Aliases | mediator complex subunit 15 |
| Synonyms | A230074L19RIK, ARC105, CAG7A, CTG7A, mediator complex subunit 15, mPcqap, PCQAP, TIG-1, TNRC7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ARC105 or Med15 subunit of Mediator complex non-fungal
- transcription regulator
- protein binding
Pathways
Biological processes and signaling networks where the Med15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Med15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- somatic stem cell maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- core mediator complex
- cytoplasm
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription cofactor activity